The Pichia pastoris expression system combines the advantages of both prokaryotic and eukaryotic expression systems. It offers several benefits, including low production costs, high-level protein expression along with post-translational modification capabilities, and genetic stability of foreign protein genes. As a result, the Pichia pastoris expression system has become increasingly favored by research institutions and pharmaceutical manufacturers. It is currently recognized as one of the most effective systems for expressing foreign proteins.
At present, biopharmaceuticals such as insulin, glucagon, growth hormone, HPV vaccine, hepatitis B vaccine, human serum albumin, coagulation factors, epidermal growth factor, tumor necrosis factor, and labialase have been produced using the Pichia pastoris expression system and are now commercially available. These products span a variety of fields, including hormones, vaccines, blood-related products, cytokines, and enzymes.